TO AITION Podcast: Key Insights and Breakthroughs from the TO_AITION Project

The TO_AITION Project proudly contributed to the CardioTalk – Latest Research podcast series organised by the European Society of Cardiology, presenting the latest insights and breakthroughs from the project. This episode highlights how TO AITION addresses the complex comorbidity between cardiovascular disease and depression, focusing on shared biological mechanisms, immunological pathways, and system-level interactions that influence disease onset, progression, and patient outcomes.

Professor Evangelos Andreakos, TO_AITION Coordinator and Head of the Immunology Lab at the Biomedical Research Foundation of the Academy of Athens (BRFAA), leads efforts to uncover immune-driven mechanisms underlying the coexistence of cardiovascular disease and depression. His team has developed experimental models combining depression and atherosclerosis, explored the role of trained innate immunity, conducted functional genomic analyses in patient-derived cells, and created human cell-based immune models. They also contribute to the construction of disease networks to identify causal relationships and predictive phenotypes.

Assistant Professor Antonis Sakellarios (University of Patras, Greece) representing partner UOI brings expertise in multiscale and AI-driven modelling, biomedical engineering, big medical data analytics, and intelligent information systems. His work ensures that TO_AITION’s research is both data-driven and highly integrative, supporting a holistic understanding of disease mechanisms.

This podcast demonstrates how interdisciplinary collaboration across immunology, systems medicine, and computational science can generate actionable knowledge to inform precision medicine approaches in cardiovascular and mental health.

Listen to the podcast: https://esc365.escardio.org/event/2455