PUBLICATIONS
Predicting early-stage coronary artery disease using machine learning and routine clinical biomarkers improved by augmented virtual data
Angela Koloi, Vasileios S Loukas, Cillian Hourican et al, European Heart Journal - Digital Health, 2024 Aug, ztae049, https://doi.org/10.1093/ehjdh/ztae049
Atherosclerotic Plaque Epigenetic Age Acceleration Predicts a Poor Prognosis and Is Associated with Endothelial-to-Mesenchymal Transition in Humans
Diez Benavente E, Hartman RJG, Sakkers TR, et al. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1419-1431. doi: 10.1161/ATVBAHA.123.320692. Epub 2024 Apr 18. PMID: 38634280.
Association between BMD and coronary artery calcification: an observational and Mendelian randomization study
Lu H, Lary CW, Hodonsky CJ, et al. J Bone Miner Res. 2024 May 2;39(4):443-452. doi: 10.1093/jbmr/zjae022. PMID: 38477752; PMCID: PMC11262143.
The Effects of FABP4 on Cardiovascular Disease in the Aging Population
van der Ark-Vonk EM, Puijk MV, Pasterkamp G, van der Laan SW. Curr Atheroscler Rep. 2024 May;26(5):163-175. doi: 10.1007/s11883-024-01196-5. Epub 2024 May 3. PMID: 38698167; PMCID: PMC11087245.
Identification of gene networks jointly associated with depressive symptoms and cardiovascular health metrics using whole blood transcriptome in the Young Finns Study
Mishra BH, Raitoharju E, Mononen N, et al. Front Psychiatry. 2024 Apr 25; 15:1345159. doi: 10.3389/fpsyt.2024.1345159. PMID: 38726387; PMCID: PMC11079127.
Sex and statin-related genetic associations at the PCSK9 gene locus: results of genome-wide association meta-analysis
Pott J, Kheirkhah A, Gadin JR, Kleber ME, Delgado GE, et al. Biol Sex Differ. 2024 Mar 26;15(1):26. doi: 10.1186/s13293-024-00602-6. PMID: 38532495; PMCID: PMC10964567.
Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis
Prapiadou S, Živković L, Thorand B, et al. Circulation. 2024 Feb 27;149(9):669-683. doi: 10.1161/CIRCULATIONAHA.123.064974. Epub 2023 Dec 28. PMID: 38152968; PMCID: PMC10922752.
Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci
Hodonsky CJ, Turner AW, Khan MD, et al. Cell Genom. 2024 Jan 10;4(1):100465. doi: 10.1016/j.xgen.2023.100465. Epub 2023 Dec 15. PMID: 38190101; PMCID: PMC10794848.
AI-Enhanced Predictive Modeling for Identifying Depression and Delirium in Cardiovascular Patients Scheduled for Cardiac Surgery
Nowakowska K, Sakellarios A, Kaźmierski J, Fotiadis DI, Pezoulas VC. Diagnostics (Basel). 2023 Dec 27;14(1):67. doi: 10.3390/diagnostics14010067. PMID: 38201376; PMCID: PMC10795764.
Evidence of survival bias in the association between APOE-ϵ4 and age of ischemic stroke onset
von Berg J, McArdle PF, Häppölä P, et al. medRxiv [Preprint]. 2023 Dec 1:2023.12.01.23294385. doi: 10.1101/2023.12.01.23294385. PMID: 38076909; PMCID: PMC10705635.
Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis
Mosquera JV, Auguste G, Wong D, et al. Cell Rep. 2023 Nov 28;42(11):113380. doi: 10.1016/j.celrep.2023.113380. Epub 2023 Nov 10. PMID: 37950869.
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Roychowdhury T, Klarin D, Levin MG, et al. Nat Genet. 2023 Nov;55(11):1831-1842. doi: 10.1038/s41588-023-01510-y. Epub 2023 Oct 16. PMID: 37845353; PMCID: PMC10632148.
A network analysis of depressive symptoms and metabolomics
Rydin AO, Milaneschi Y, Quax R, Li J, et al. Psychol Med. 2023 Nov;53(15):7385-7394. doi: 10.1017/S0033291723001009. Epub 2023 Apr 24. PMID: 37092859; PMCID: PMC10719687.
The accumulation of erythrocytes quantified and visualized by Glycophorin C in carotid atherosclerotic plaque reflects intraplaque hemorrhage and pre-procedural neurological symptoms
Mekke JM, Sakkers TR, Verwer MC, et al. Sci Rep. 2023 Oct 10;13(1):17104. doi: 10.1038/s41598-023-43369-3. PMID: 37816779; PMCID: PMC10564864.
Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification
Kavousi M, Bos MM, Barnes HJ, et al. Nat Genet. 2023 Oct;55(10):1651-1664. doi: 10.1038/s41588-023-01518-4. Epub 2023 Sep 28. PMID: 37770635; PMCID: PMC10601987.
Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome-Wide Association Meta-Analysis Followed by Mendelian Randomization
Zheng J, Wheeler E, Pietzner M, et al. Arthritis Rheumatol. 2023 Oct;75(10):1781-1792. doi: 10.1002/art.42538. Epub 2023 Aug 3. PMID: 37096546; PMCID: PMC10586470.
The metabolome-wide signature of major depressive disorder
Jansen R, Milaneschi Y, Schranner D, et al. Res Sq [Preprint]. 2023 Sep 21: rs.3.rs-3127544. doi: 10.21203/rs.3.rs-3127544/v1. Update in: Mol Psychiatry. 2024 Jun 7. doi: 10.1038/s41380-024-02613-6. PMID: 37790319; PMCID: PMC10543022.
Proteomic Atlas of Atherosclerosis: The Contribution of Proteoglycans to Sex Differences, Plaque Phenotypes, and Outcomes
Theofilatos K, Stojkovic S, Hasman M, et al. Circ Res. 2023 Sep 15;133(7):542-558. doi: 10.1161/CIRCRESAHA.123.322590. Epub 2023 Aug 30. PMID: 37646165; PMCID: PMC10498884.
Genetic insights into resting heart rate and its role in cardiovascular disease
van de Vegte YJ, Eppinga RN, van der Ende MY, et al. Nat Commun. 2023 Aug 2;14(1):4646. doi: 10.1038/s41467-023-39521-2. PMID: 37532724; PMCID: PMC10397318.
A comparison study on creating simulated patient data for individuals suffering from chronic coronary disorders.
Koloi A, Loukas VS, Sakellarios A, et al. Annu Int Conf IEEE Eng Med Biol Soc. 2023 Jul;2023:1-4. doi: 10.1109/EMBC40787.2023.10340194. PMID: 38082601.
Antithrombin, Protein C, and Protein S: Genome and Transcriptome-Wide Association Studies Identify 7 Novel Loci Regulating Plasma Levels
Ji Y, Temprano-Sagrera G, Holle LA, Bebo A, et al. Arterioscler Thromb Vasc Biol. 2023 Jul;43(7):e254-e269. doi: 10.1161/ATVBAHA.122.318213. Epub 2023 Apr 27. PMID: 37128921; PMCID: PMC10330350.
X chromosome inactivation skewing is common in advanced carotid atherosclerotic lesions in females and predicts secondary peripheral artery events
Buono MF, Benavente ED, Daniels M, et al. Biol Sex Differ. 2023 Jul 5;14(1):43. doi: 10.1186/s13293-023-00527-6. PMID: 37408072; PMCID: PMC10324263.
Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy
Overmars LM, Mekke JM, van Solinge WW, et al. Atheroscler Plus. 2023 Jun 1;52:32-40. doi: 10.1016/j.athplu.2023.05.003. PMID: 37389152; PMCID: PMC10300576.
High genetic risk for depression as an independent risk factor for mortality in patients referred for coronary angiography
Krämer RM, Moissl AP, Lorkowski S, Krämer BK, et al. Front Cardiovasc Med. 2023 Jun 26;10:1125151. doi: 10.3389/fcvm.2023.1125151. PMID: 37435051; PMCID: PMC10330785.
Metabolomics signatures of depression: the role of symptom profiles
de Kluiver H, Jansen R, Penninx BWJH, Giltay EJ, Schoevers RA, Milaneschi Y.
Transl Psychiatry. 2023 Jun 10;13(1):198. doi: 10.1038/s41398-023-02484-5. PMID: 37301859; PMCID: PMC10257720.
DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood
Hahn J, Bressler J, Domingo-Relloso A, Chen MH, et al. J Thromb Haemost. 2023 May;21(5):1135-1147. doi: 10.1016/j.jtha.2023.01.015. Epub 2023 Jan 28. PMID: 36716967.
Plasma Lipoprotein Lipase Is Associated with Risk of Future Major Adverse Cardiovascular Events in Patients Following Carotid Endarterectomy
Mekke JM, Verwer MC, Stroes ESG, et al. Eur J Vasc Endovasc Surg. 2023 May;65(5):700-709. doi: 10.1016/j.ejvs.2023.01.035. Epub 2023 Jan 26. PMID: 36708756.
Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity
Schmidt AF, Bourfiss M, Alasiri A, et al. Sci Adv. 2023 Apr 28;9(17): eadd4984. doi: 10.1126/sciadv. add4984. Epub 2023 Apr 26. PMID: 37126556; PMCID: PMC10132758.
An automatic entropy method to efficiently mask histology whole-slide images
Song Y, Cisternino F, Mekke JM, et al. Sci Rep. 2023 Mar 15;13(1):4321. doi: 10.1038/s41598-023-29638-1. PMID: 36922520; PMCID: PMC10017682.
Effect of tissue-grouped regulatory variants associated to type 2 diabetes in related secondary outcomes
Hemerich D, Smit RAJ, Preuss M, Stalbow L, van der Laan SW, et al. Sci Rep. 2023 Mar 2;13(1):3579. doi: 10.1038/s41598-023-30369-6. PMID: 36864090; PMCID: PMC9981672.
Platelet Reactivity and Cardiovascular Mortality Risk in the LURIC Study
Berger M, Dressel A, Kleber ME, März W, et al. J Clin Med. 2023 Feb 28;12(5):1913. doi: 10.3390/jcm12051913. PMID: 36902699; PMCID: PMC10003439.
LoFTK: a framework for fully automated calculation of predicted Loss-of-Function variants and genes
Alasiri A, Karczewski KJ, Cole B, et al. BioData Min. 2023 Feb 2;16(1):3. doi: 10.1186/s13040-023-00321-5. PMID: 36732776; PMCID: PMC9893534.
Mekke JM, Verwer MC, Stroes ESG, Kroon J, Timmers L, Pasterkamp G, de Borst GJ, van der Laan SW, de Kleijn DPV. Eur J Vasc Endovasc Surg. 2023 Jan 26: S1078-5884(23)00069-2. doi: 10.1016/j.ejvs.2023.01.035. Epub ahead of print. PMID: 36708756.
Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values |
OMICS: A Journal of Integrative Biology (liebertpub.com)
Drouard G, Ollikainen M, Mykkänen J, Raitakari O, Lehtimäki T, Kähönen M, Mishra PP, Wang X, Kaprio J.
OMICS: A Journal of Integrative Biology.130-141 (2022).
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Mishra BH, Sievänen H, Raitoharju E, Mononen N, Viikari J, Juonala M, Laaksonen M, Hutri-Kähönen N, Kähönen M, Raitakari OT, Lehtimäki T, Mishra PP. Atherosclerosis 2022 Nov;361:1-9. doi: 10.1016/j.atherosclerosis.2022.10.005. Epub 2022 Oct 8. PMID: 36252457.
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How location and cellular signaling combine to activate the NLRP3 inflammasome |
Cellular & Molecular Immunology (nature.com)
Akbal A, Dernst A, Lovotti M, Mangan MSJ, McManus RM, Latz E. ​ Cell Mol Immunol. 2022 Nov;19(11):1201-1214. doi: 10.1038/s41423-022-00922-w. Epub 2022 Sep 20. PMID: 36127465; PMCID: PMC9622870.
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Slenders L, Tessels DE, van der Laan SW, Pasterkamp G and Mokry M Front Cardiovasc Med. 2022 Feb 8;9:826103. doi: 10.3389/fcvm.2022.826103. PMID: 35211529; PMCID: PMC8860895.
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PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS summary statistics |
Bioinformatics | Oxford Academic (oup.com)
von Berg J., ten Dam M., van der Laan S. W., de Ridder J., Bioinformatics. 2022 Jun 24;38 (Suppl 1): i212-i219. doi: 10.1093/bioinformatics/btac228. PMID: 35758773; PMCID: PMC9235478.
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The gut microbiota and depressive symptoms across ethnic groups | Nature Communications
Bosch JA, Nieuwdorp M, Zwinderman AH, Deschasaux M, Radjabzadeh D, Kraaij R, Davids M, de Rooij SR, Lok A. Nat Commun. 2022 Dec 6;13(1):7129. doi: 10.1038/s41467-022-34504-1. PMID: 36473853; PMCID: PMC9726934.
Gut microbiome-wide association study of depressive symptoms | Nature Communications
Radjabzadeh D, Bosch JA, Uitterlinden AG, Zwinderman AH, Ikram MA, van Meurs JBJ, Luik AI, Nieuwdorp M, Lok A, van Duijn CM, Kraaij R, Amin N. Nat Commun. 2022 Dec 6;13(1):7128. doi: 10.1038/s41467-022-34502-3. PMID: 36473852; PMCID: PMC9726982.
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Assessment of plasma ceramides as predictor for subclinical atherosclerosis.
Pashupati P. Mishra, Binisha H. Mishra, Leo-Pekka Lyytikäinen, Mika Hilvo, Markus Juonala, Mika Kähönen, Nina Hutri-Kähönen, Dimitrios I. Fotiadis, Olli T. Raitakari, Reijo Laaksonen, Terho Lehtimäki, Atheroscler Plus. 2021 Oct 2; 45:25-31. doi: 10.1016/j.athplu.2021.09.005. PMID: 36643994; PMCID: PMC9833256.
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Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression.
Yuri Milaneschi, Matthias Arnold, Gabi Kastenmüller, Siamak Mahmoudian Dehkordi, Ranga R. Krishnan, Boadie W. Dunlop, A. John Rush, Brenda W. J. H. Penninx, Rima Kaddurah-Daouk, for the Mood Disorders Precision Medicine Consortium (MDPMC). J Affect Disord. 2022 Jun 15; 307:254-263. doi: 10.1016/j.jad.2022.03.070. Epub 2022 Apr 2. PMID: 35381295.