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Frontiers | Combined Use of Serum Uromodulin and eGFR to Estimate Mortality Risk (

Yazdani B, Delgado GE, Scharnagl H, Krämer BK, Drexel H, März W, Scherberich JE, Leiherer A and Kleber ME (2021) Front. Med. 8:723546. 

 Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values | OMICS: A Journal of Integrative Biology (

Gabin Drouard, et al. OMICS: A Journal of Integrative Biology. Mar 2022.130-141.

Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies - Kidney International (

Gorski Mathias, et al. CLINICAL INVESTIGATION| volume 102, issue 3, p624-639, Sept (2022)


Does social intolerance vary according to cognitive styles, genetic cognitive capacity, or education? - Saarinen - 2022 - Brain and Behavior - Wiley Online Library

Saarinen A., et al. Brain and Behavior, 12, (2022) e2704.


Schizophrenia polygenic risk score and long-term success in the labour market: A cohort study - ScienceDirect

Jutta Viinikainen, et al. Journal of Psychiatric Research, Volume 151, 2022, Pages 638-641


Evaluation of the QRS score for diagnosing coronary artery disease in women: A Finnish cardiovascular study - Beyene - 2022 - Annals of Noninvasive Electrocardiology - Wiley Online Library

Beyene, S. D. et al. Annals of Noninvasive Electrocardiology, 27, (2022).  e12968




Magical thinking in individuals with high polygenic risk for schizophrenia but no non-affective psychoses

-a general population study | Molecular Psychiatry (

Saarinen, A., Lyytikäinen, LP., Hietala, J. et al. Mol Psychiatry 27, 3286–3293 (2022)


Interatrial block and P terminal force in the general population –

Longitudinal changes, risk factors and prognosis - ScienceDirect

Istolahti T, et al. J Electrocardiol. 2022 Jul-Aug; 73:12-20.



BMI is positively associated with accelerated epigenetic aging in twin pairs discordant for body mass index - Lundgren - 2022 - Journal of Internal Medicine - Wiley Online Library

Lundgren, S, et al. J Intern Med. 2022; 292: 627– 640


Frontiers | Changes in BMI and physical activity from youth to adulthood distinguish normal-weight, metabolically obese adults from those who remain healthy (

Viitasalo A., et al. Frontiers in Endocrinology. VOL.13 (2022)  




Gene set analysis of transcriptomics data identifies new biological processes associated with early markers of atherosclerosis but not with those of osteoporosis: Atherosclerosis-osteoporosis co/multimorbidity study in the Young Finns Study - Atherosclerosis (

Mishra, B.H., et al. vol 361, P1-9, Nov 2022

Genetics of osteopontin in patients with chronic kidney disease:

The German Chronic Kidney Disease study | PLOS Genetics

Yurong Cheng, et al. Plos Gen. April 6, 2022



[2102.11690] Inferring temporal dynamics from cross-sectional data using Langevin dynamics (

Pritha Dutta et al, arXiv, 23 Feb 2021 arXiv:2102.11690v1



Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

European Heart Journal | Oxford Academic (

Jaana A Hartiala, et al. European Heart Journal, Volume 42, Issue 9, 1 March 2021, Pages 919–933




Circulating cell-free DNA level predicts all-cause mortality independent of other predictors

in the Health 2000 survey | Scientific Reports (

Kananen, L., et al. Sci Rep 10, 13809 (2020).



The S1S2S3 electrocardiographic pattern — Prevalence and relation to cardiovascular and pulmonary diseases

in the general population - ScienceDirect

Joonas Nurminen, et al., Journal of Electrocardiology, Volume 73, 2022.




A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection | Nature Immunology

Andreakos, E., Abel, L., Vinh, D.C. et al. Nat Immunol 23, 159–164 (2022).



Associations of long-term solar insolation with specific depressive symptoms:

Evidence from a prospective cohort study - ScienceDirect

Kaisla Komulainen, et al. Journal of Psychiatric Research,Volume 151,2022, Pages 606-610


Organized Youth Sports Trajectories and Adult Health Outcomes:

The Young Finns Study - American Journal of Preventive Medicine (

Xiaolin Yang, et al. AJPM, volume 63, issue 6, p962-970, Dec 2022


The relationship between temperament, polygenic score for intelligence and cognition: A population‐based study of middle‐aged adults - Tölli - 2022 - Genes, Brain and Behavior - Wiley Online Library

Tölli, P, Keltikangas-Järvinen, L, Lehtimäki, T, et al. Genes, Brain and Behavior. 2022; 21(4): e12798.


Long-term tracking and population characteristics of lipoprotein (a) in the

Cardiovascular Risk in Young Finns Study - Atherosclerosis (

Olli Raitakari, et al. Atherosclerosis volume 356, p18-27, Sept 2022

How location and cellular signaling combine to activate the NLRP3 inflammasome |

Cellular & Molecular Immunology (

Akbal, A., Dernst, A., Lovotti, M. et al. Cell Mol Immunol 19, 1201–1214 (2022)

Red blood cell fatty acid patterns from 7 countries: Focus on the Omega-3 index - Prostaglandins,

Leukotrienes and Essential Fatty Acids (

179:102418 (2022)


Unfolding and disentangling coronary vascular disease through genome-wide association studies |

European Heart Journal | Oxford Academic (

Erdmann, J., van der Laan, S. W., European Heart Journal Volume 42, Issue 9, 934–937 (2021)


Frontiers | PlaqView 2.0: A comprehensive web portal for cardiovascular single-cell genomics (

Ma WF, Turner AW, Gancayco C, Wong D, Song Y, Mosquera JV, Auguste G, Hodonsky CJ, Prabhakar A, Ekiz HA, van der Laan SW and Miller CL Front. Cardiovasc. Med. 9:969421 (2022)

Frontiers | Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease: An Individual-Level Meta-Analysis (

Schillemans T, Tragante V, Maitusong B, et al. Front. Physiol. 13:909870 (2022)


Intersecting single-cell transcriptomics and genome-wide association studies identifies crucial cell populations and candidate genes for atherosclerosis | European Heart Journal Open | Oxford Academic (

Lotte Slenders, Lennart P L Landsmeer, et al., European Heart Journal Open, Volume 2, Issue 1(2022)


Frontiers | The Applications of Single-Cell RNA Sequencing in Atherosclerotic Disease (

Slenders L, Tessels DE, van der Laan SW, Pasterkamp G and Mokry M Front. Cardiovasc. Med. 9:826103 (2022)



PolarMorphism enables discovery of shared genetic variants across multiple traits from GWAS

summary statistics | Bioinformatics | Oxford Academic (

von Berg J., ten Dam M., van der Laan S. W., de Ridder J., Bioinformatics, Volume 38, Issue Supplement_1, i212–i219 (2022)


A saturated map of common genetic variants associated with human height | Nature

Yengo, L., Vedantam, S., Marouli, E. et al.  Nature 610, 704–712 (2022).


The gut microbiota and depressive symptoms across ethnic groups | Nature Communications

Bosch, J.A., Nieuwdorp, M., Zwinderman, A.H. et al. Nat Commun 13, 7129 (2022).


Gut microbiome-wide association study of depressive symptoms | Nature Communications

Radjabzadeh, D., Bosch, J.A., Uitterlinden, A.G. et al. Nat Commun 13, 7128 (2022).

DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases.

Wielscher, M., Mandaviya, P.R., Kuehnel, B. et al. Nat Commun 13, 2408 (2022)


Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases.

Yong Li, Luca Rampoldi, Anna Köttgen. JCI Insight (2022)

Genome-wide meta-analysis of phytosterols reveals five novel loci and

a detrimental effect on coronary atherosclerosis.

Scholz, M., Horn, K., Pott, J. et al. Nat Commun 13, 143 (2022)


Reproductive history and blood cell DNA methylation later in life: the Young Finns Study.

Harville, E.W., Mishra, P.P., Kähönen, M. et al. Clin Epigenet 13, 227 (2021) 

Assessment of plasma ceramides as predictor for subclinical atherosclerosis.

Pashupati P. Mishra, Binisha H. Mishra, Leo-Pekka Lyytikäinen, Mika Hilvo, Markus Juonala, Mika Kähönen, Nina Hutri-Kähönen, Dimitrios I. Fotiadis, Olli T. Raitakari, Reijo Laaksonen, Terho Lehtimäki,  Atherosclerosis Plus, Volume 45, Pages 25-31 (2021)

Genomics-based identification of a potential causal role for acylcarnitine metabolism in depression.

Yuri Milaneschi, Matthias Arnold, Gabi Kastenmüller, Siamak Mahmoudian Dehkordi, Ranga R. Krishnan, Boadie W. Dunlop, A. John Rush, Brenda W. J. H. Penninx, Rima Kaddurah-Daouk, for the Mood Disorders Precision Medicine Consortium (MDPMC). medRxiv 2021.10.18.21265157 (2021)

Mitochondrial genome-wide analysis of nuclear DNA methylation quantitative trait loci,

Jaakko Laaksonen, Pashupati P Mishra, Ilkka Seppälä, Emma Raitoharju, Saara Marttila, Nina Mononen, Leo-Pekka Lyytikäinen, Marcus E Kleber, Graciela E Delgado, Maija Lepistö, Henrikki Almusa, Pekka Ellonen, Stefan Lorkowski, Winfried März, Nina Hutri-Kähönen, Olli Raitakari, Mika Kähönen, Jukka T Salonen, Terho Lehtimäki, Human Molecular Genetics (2021)

Uncovering the shared lipidomic markers of subclinical osteoporosis-atherosclerosis comorbidity: The Young Finns Study, Binisha H. Mishra, Pashupati P. Mishra, Nina Mononen, Mika Hilvo, Harri Sievänen, Markus Juonala, Marika Laaksonen, Nina Hutri-Kähönen, Jorma Viikari, Mika Kähönen, Olli T. Raitakari, Reijo Laaksonen, Terho Lehtimäki, Bone, Volume 151,116030 (2021)


Association between Oral Pathology, Carotid Stenosis, and Oral Bacterial DNA in Cerebral Thrombi of Patients with Stroke, Olli Patrakka, Helena Mehtonen, Sari Tuomisto, Juha-Pekka Pienimäki, Jyrki Ollikainen, Heini Huhtala, Tanja Pessi, Niku Oksala, Terho Lehtimäki,

Jorma Järnstedt, Mika Martiskainen, Pekka J. Karhunen, Stroke Research and Treatment, vol. 2021 (2021)


Genetic differential susceptibility to the parent–child relationship quality and the life span development of compassion. Henrik Dobewall, Liisa Keltikangas-Järvinen, Aino Saarinen, Leo-Pekka Lyytikäinen, Igor Zwir, Robert Cloninger, Olli T. Raitakari,

Terho Lehtimäki, Mirka Hintsanen,  Developmental Psychobiology, 63, e22184 (2021)

C-reactive protein and temperament: An instrumental variable analysis,

Ari Clemens, Pashupati P. Mishra, Eirini Flouri, Terho Lehtimäki, Olli Raitakari, Liisa Keltikangas-Järvinen, Katriina Heikkilä,

Brain, Behavior, & Immunity - Health, Volume 14 (2021)

Methylation status of nc886 epiallele reflects periconceptional conditions and is associated

with glucose metabolism through nc886 RNAs.

Marttila, S., Viiri, L.E., Mishra, P.P. et al. Clin Epigenet 13, 143 (2021)


Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.

McCartney, D.L., Min, J.L., Richmond, R.C. et al. Genome Biol 22, 194 (2021)

Meta-analysis of epigenome-wide association studies of carotid intima-media thickness.

Portilla-Fernández, E., Hwang, SJ., Wilson, R. et al. Eur J Epidemiol 36, 1143–1155 (2021)


Prehospital Adenosine Diphosphate Receptor Blocker Use, Culprit Artery Flow, and Mortality in STEMI: The MADDEC Study. Hautamäki M, Lyytikäinen LP, Eskola M, et al. Clin Drug Investig. 41(7):605-613 (2021)


Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health.

Marttila, S., Rovio, S., Mishra, P.P. et al. Sci Rep 11, 9203 (2021)


Modular genome-wide gene expression architecture shared by early traits

of osteoporosis and atherosclerosis in the Young Finns

Study. Mishra, B.H., Mishra, P.P., Raitoharju, E. et al. Sci Rep 11, 7111 (2021)

The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease.

Kalaoja, M., Corbin, L.J., Tan, V.Y., Ahola-Olli, A.V., Havulinna, A.S., Santalahti, K., Pitkänen, N., Lehtimäki, T., Lyytikäinen, L.-P., Raitoharju, E., Seppälä, I., Kähönen, M., Ripatti, S., Palotie, A., Perola, M., Viikari, J.S., Jalkanen, S., Maksimow, M., Salomaa, V., Salmi, M., Raitakari,

O.T., Kettunen, J. and Timpson, N.J. Obesity, 29: 428-437 (2021)

Examining the effect of mitochondrial DNA variants on blood pressure in two Finnish cohorts.

Laaksonen, J., Mishra, P.P., Seppälä, I. et al. Sci Rep 11, 611 (2021)

The prognostic significance of T-wave inversion according to ECG lead group

during long-term follow-up in the general population.

Istolahti, T, Lyytikäinen, L-P, Huhtala, H, et al. Ann Noninvasive Electrocardiol. 26:e12799 (2021)


DNA methylation signatures of aggression and closely related constructs:

A meta-analysis of epigenome-wide studies across the lifespan.

van Dongen, J., Hagenbeek, F.A., Suderman, M. et al. Mol Psychiatry 26, 2148–2162 (2021)


Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.

Gorski, MathiasAlizadeh, Behrooz Z.Abecasis, Goncalo et al., Kidney International, Volume 99, Issue 4, 926 - 939 (2020)

Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study.

Pashupati P. Mishra, Ismo Hänninen, Emma Raitoharju, Saara Marttila, Binisha H. Mishra, Nina Mononen, Mika Kähönen, Mikko Hurme, Olli Raitakari, Petri Törönen, Liisa Holm, Terho Lehtimäki; Biosci Rep; 40 (7): BSR20200596 (2020)


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