Project Objectives

OBJ1 | To build maps of immune cell-specific genomic, epigenomic, transcriptomic and proteomic

characteristics from healthy individuals and patients.

OBJ2 | To characterize CVD-depression multimorbidity phenotypes, imune-metabolic profiles and pathobiological states linked to clinical phenotypes through systems biology and artificial intelligence approaches

OBJ3 | To identify common mechanisms, risk and susceptibility factors driving co/multimorbidities through hypothesis and data-driven high dimensional approaches, and causal inference studies

OBJ4 Evaluation of causality of novel factors and pathways identified in purpose-built human cellbased and animal models

OBJ5 To identify novel biomarkers for the diagnosis, prognosis and monitoring of CVD-depression multimorbidities

OBJ6 To develop a novel lab-on-chip test for the diagnosis, prognosis and monitoring of CVDdepression multimorbidities in patients

OBJ7 To develop a new multiscale risk model to identify high versus low risk states to assist the diagnosis

and management of CVD-depression multimorbidities

OBJ8 | To plan medical professionals and patients-focused awareness programs and

educational activities for CVD-depression multimorbidities