A high-dimensional approach for unwinding immune-metabolic causes of

cardiovascular disease-depression multimorbidities

Depression is a common and serious comorbidity of cardiovascular disease (CVD) affecting one in three patients, among which women earlier and more frequently. Depression increases the risk for CVD development, acute events and mortality by >2 fold, independently of traditional risk factors, and constitutes an enormous socioeconomic burden in terms of morbidity, mortality and healthcare costs. Still, the patients at risk, disease trajectories and causative mechanisms involved remain unknown.

TO_AITION addresses the hypothesis that immune-metabolic dysregulation, occurring as a result of genetic, lifestyle and environmental risk factors ‘training’ innate immunity, drives low grade systemic inflammation leading to the development of CVD-depression comorbidity. 

TO_AITION will therefore rationally change our current understanding of the causative mechanisms driving CVD-depression comorbidity, unravelling patients’ complexity and improving their diagnosis, monitoring and management.


 Centre for Clinical, Experimental Surgery & Translational Research

Soranou Efesiou 4, Athens, Greece

Dr Evangelos Andreakos



This project has received funding from the European Union’s Horizon 2020 research

and innovation programme under grant agreement No 848146

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The European Commission is not responsible for any use that may be made of the information it contains

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